Wednesday, December 10, 2008

Cholinesterase inhibitors reduce aggression, wandering and paranoia in Alzheimer's disease

From Caring Kay b.:

Cholinesterase inhibitors, used to treat cognitive
symptoms of Alzheimer's disease, are also a safe and effective
alternative therapy for the behavioral and psychological symptoms of
dementia, according to a study that appears in the December 2008
edition of Clinical Interventions in Aging.

Investigators
from the Indiana University School of Medicine, the Regenstrief
Institute and Wishard Health Services reviewed nine randomized,
double-blind, placebo-controlled clinical trials evaluating the
effectiveness of three popular cholinesterase inhibitors in managing
behavioral and psychological symptoms displayed by patients with
Alzheimer's disease.

The researchers
report that the trial results indicate cholinesterase inhibitors led to
a statistically significant reduction in behavioral and psychological
symptoms such as aggression, wandering or paranoia when using the same
dosage as administered for improving cognitive impairment.

EurekAlert > full article


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